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Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administra...

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書目詳細資料
發表在:PLoS One
Main Authors: Hohlbaum, Katharina, Bert, Bettina, Dietze, Silke, Palme, Rupert, Fink, Heidrun, Thöne-Reineke, Christa
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472303/
https://ncbi.nlm.nih.gov/pubmed/28617851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179588
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