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Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administra...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Hohlbaum, Katharina, Bert, Bettina, Dietze, Silke, Palme, Rupert, Fink, Heidrun, Thöne-Reineke, Christa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472303/
https://ncbi.nlm.nih.gov/pubmed/28617851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179588
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