Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administra...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hohlbaum, Katharina, Bert, Bettina, Dietze, Silke, Palme, Rupert, Fink, Heidrun, Thöne-Reineke, Christa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472303/
https://ncbi.nlm.nih.gov/pubmed/28617851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179588
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