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Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro
Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner....
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5472167/ https://ncbi.nlm.nih.gov/pubmed/28593940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15589 |
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