Anti-high Mobility Group Box 1 Antibody Ameliorates Albuminuria in MRL/lpr Lupus-Prone Mice

We evaluated the efficacy of a neutralizing anti-high mobility group box 1 (HMGB1) monoclonal antibody in MRL/lpr lupus-prone mice. The anti-HMGB1 monoclonal antibody (5 mg/kg weight) or class-matched control immunoglobulin G2a (IgG2a) was administered intravenously twice a week for 4–15 weeks. Urin...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Watanabe, Haruki, Watanabe, Katsue S., Liu, Keyue, Hiramatsu, Sumie, Zeggar, Sonia, Katsuyama, Eri, Tatebe, Noriko, Akahoshi, Akiya, Takenaka, Fumiaki, Hanada, Takahisa, Akehi, Masaru, Sasaki, Takanori, Sada, Ken-ei, Matsuura, Eiji, Nishibori, Masahiro, Wada, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472134/
https://ncbi.nlm.nih.gov/pubmed/28649578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.05.006
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