Anaphylatoxins Activate Ca(2+), Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

PURPOSE: The retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells; here, we explore whether they trigger RPE a...

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Udgivet i:Front Immunol
Main Authors: Busch, Catharina, Annamalai, Balasubramaniam, Abdusalamova, Khava, Reichhart, Nadine, Huber, Christian, Lin, Yuchen, Jo, Emeraldo A. H., Zipfel, Peter F., Skerka, Christine, Wildner, Gerhild, Diedrichs-Möhring, Maria, Rohrer, Bärbel, Strauß, Olaf
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472091/
https://ncbi.nlm.nih.gov/pubmed/28663750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00703
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