Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells

BACKGROUND: Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considering that t...

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Publicado en:Arthritis Res Ther
Main Authors: Urushima, Hayato, Fujimoto, Minoru, Mishima, Takashi, Ohkawara, Tomoharu, Honda, Hiromi, Lee, Hyun, Kawahata, Hirohisa, Serada, Satoshi, Naka, Tetsuji
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471956/
https://ncbi.nlm.nih.gov/pubmed/28615031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1349-2
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