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Cryo-EM structures of human recombinase RAD51 filaments in the catalysis of DNA strand exchange

The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA strand exchange mediated by the Rad51 recombinase. In this process, Rad51 assembles on single-stranded DNA (ssDNA) to yield a helical filament that is able to search for and invade a homologous double-stranded DNA (dsD...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Xu, Jingfei, Zhao, Lingyun, Xu, Yuanyuan, Zhao, Weixing, Sung, Patrick, Wang, Hong-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471492/
https://ncbi.nlm.nih.gov/pubmed/27941862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3336
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