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Cryo-EM structures of human recombinase RAD51 filaments in the catalysis of DNA strand exchange
The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA strand exchange mediated by the Rad51 recombinase. In this process, Rad51 assembles on single-stranded DNA (ssDNA) to yield a helical filament that is able to search for and invade a homologous double-stranded DNA (dsD...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5471492/ https://ncbi.nlm.nih.gov/pubmed/27941862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3336 |
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