Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP

Glioblastomas (GBM) are the most malignant brain tumors in humans and have a very poor prognosis. New therapeutic options are urgently needed. A novel drug, Vacquinol-1 (Vac), a quinolone derivative, displays promising properties by inducing rapid cell death in GBM but not in non-transformed tissues...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Sander, Philip, Mostafa, Haouraa, Soboh, Ayman, Schneider, Julian M., Pala, Andrej, Baron, Ann-Kathrin, Moepps, Barbara, Wirtz, C. Rainer, Georgieff, Michael, Schneider, Marion
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471040/
https://ncbi.nlm.nih.gov/pubmed/28410232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16703
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