Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells

In glioblastoma several histone demethylase genes (KDM) are overexpressed compared to normal brain tissue and the development of Temozolomide (TMZ) resistance is accompanied by the transient further increased expression of KDM5A and other KDMs following a mechanism that we defined as “epigenetic res...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Banelli, Barbara, Daga, Antonio, Forlani, Alessandra, Allemanni, Giorgio, Marubbi, Daniela, Pistillo, Maria Pia, Profumo, Aldo, Romani, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471020/
https://ncbi.nlm.nih.gov/pubmed/28432280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16820
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