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Understanding ligand-receptor non-covalent binding kinetics using molecular modeling

Kinetic properties may serve as critical differentiators and predictors of drug efficacy and safety, in addition to the traditionally focused binding affinity. However the quantitative structure-kinetics relationship (QSKR) for modeling and ligand design is still poorly understood. This review provi...

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Publicado en:Front Biosci (Landmark Ed)
Main Authors: Tang, Zhiye, Roberts, Christopher C., Chang, Chia-en A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470370/
https://ncbi.nlm.nih.gov/pubmed/27814657
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