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Understanding ligand-receptor non-covalent binding kinetics using molecular modeling

Kinetic properties may serve as critical differentiators and predictors of drug efficacy and safety, in addition to the traditionally focused binding affinity. However the quantitative structure-kinetics relationship (QSKR) for modeling and ligand design is still poorly understood. This review provi...

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Détails bibliographiques
Publié dans:Front Biosci (Landmark Ed)
Auteurs principaux: Tang, Zhiye, Roberts, Christopher C., Chang, Chia-en A.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470370/
https://ncbi.nlm.nih.gov/pubmed/27814657
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