Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

The resistance of tumor cells to chemotherapeutic drugs is a major obstacle to successful cancer chemotherapy. In human cells, expression of the MDR1 gene, encoding a transmembrane efflux pump (P-glycoprotein), leads to decreased intracellular accumulation and resistance to a variety of lipophilic d...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Noonan, K E, Beck, C, Holzmayer, T A, Chin, J E, Wunder, J S, Andrulis, I L, Gazdar, A F, Willman, C L, Griffith, B, Von Hoff, D D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54703/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1976252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.18.7160
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