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An investigation into the effects of excipient particle size, blending techniques and processing parameters on the homogeneity and content uniformity of a blend containing low-dose model drug

Powder blend homogeneity is a critical attribute in formulation development of low dose and potent active pharmaceutical ingredients (API) yet a complex process with multiple contributing factors. Excipient characteristics play key role in efficient blending process and final product quality. In thi...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Alyami, Hamad, Dahmash, Eman, Bowen, James, Mohammed, Afzal R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469472/
https://ncbi.nlm.nih.gov/pubmed/28609454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178772
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