Glucose 6-Phosphate Dehydrogenase Deficiency Increases Redox Stress and Moderately Accelerates the Development of Heart Failure

BACKGROUND: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world. In failing hearts, G6PD is upregulated and generates NADPH that is used by the glutathione pathway to remove reactive oxygen species (ROS), but also as a substrate by ROS-generating enz...

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Pubblicato in:Circ Heart Fail
Autori principali: Hecker, Peter A., Lionetti, Vincenzo, Ribeiro, Rogerio F., Rastogi, Sharad, Brown, Bethany H., O’Connell, Kelly A., Cox, James W., Shekar, Kadambari C., Gamble, Dionna, Sabbah, Hani N., Leopold, Jane A., Gupte, Sachin A., Recchia, Fabio A., Stanley, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469404/
https://ncbi.nlm.nih.gov/pubmed/23170010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.969576
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