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Effects of local and spinal administrations of mu-opioids on postoperative pain in aged vs adult mice

INTRODUCTION: Suboptimal management of postoperative pain leads to increased risk of chronic opioid therapy, especially in elderly patients. OBJECTIVES: Although this age-dependent phenomenon has been observed clinically, basic mechanisms including baseline nociception, postoperative hypersensitivit...

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Detalhes bibliográficos
Publicado no:Pain Rep
Main Authors: Mecklenburg, Jennifer, Patil, Mayur J., Koek, Wouter, Akopian, Armen N.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469295/
https://ncbi.nlm.nih.gov/pubmed/28626834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PR9.0000000000000584
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