Simian Immunodeficiency Virus Targeting of CXCR3(+) CD4(+) T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets

Glycosylation of Env defines pathogenic properties of simian immunodeficiency virus (SIV). We previously demonstrated that pathogenic SIVmac239 and a live-attenuated, quintuple deglycosylated Env mutant (Δ5G) virus target CD4(+) T cells residing in different tissues during acute infection. SIVmac239...

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Bibliographic Details
Published in:J Virol
Main Authors: Fujino, Masayuki, Sato, Hirotaka, Okamura, Tomotaka, Uda, Akihiko, Takeda, Satoshi, Ahmed, Nursarat, Shichino, Shigeyuki, Shiino, Teiichiro, Saito, Yohei, Watanabe, Satoru, Sugimoto, Chie, Kuroda, Marcelo J., Ato, Manabu, Nagai, Yoshiyuki, Izumo, Shuji, Matsushima, Kouji, Miyazawa, Masaaki, Ansari, Aftab A., Villinger, Francois, Mori, Kazuyasu
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469254/
https://ncbi.nlm.nih.gov/pubmed/28424283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00439-17
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