Impairment of early fracture healing by skeletal muscle trauma is restored by FK506

BACKGROUND: Heightened local inflammation due to muscle trauma or disease is associated with impaired bone regeneration. METHODS: We hypothesized that FK506, an FDA approved immunomodulatory compound with neurotrophic and osteogenic effects, will rescue the early phase of fracture healing which is i...

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Detalhes bibliográficos
Publicado no:BMC Musculoskelet Disord
Main Authors: Hurtgen, Brady J., Henderson, Beth E. P., Ward, Catherine L., Goldman, Stephen M., Garg, Koyal, McKinley, Todd O., Greising, Sarah M., Wenke, Joseph C., Corona, Benjamin T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469075/
https://ncbi.nlm.nih.gov/pubmed/28606129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-017-1617-y
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