Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells

Homeobox a1 (Hoxa1) is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed Hox gene in the mouse embryo. In this study, we used genomic approaches to identify Hoxa1-bound regions during early stages of ES cell differentiation into the neuro-ectoderm. Wit...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: De Kumar, Bony, Parker, Hugo J., Parrish, Mark E., Lange, Jeffrey J., Slaughter, Brian D., Unruh, Jay R., Paulson, Ariel, Krumlauf, Robb
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Sackler Colloquium on Gene Regulatory Networks and Network Models in Development and Evolution
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468655/
https://ncbi.nlm.nih.gov/pubmed/28584089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610612114
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