The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier

Podocytes form the outer part of the glomerular filter, where they have to withstand enormous transcapillary filtration forces driving glomerular filtration. Detachment of podocytes from the glomerular basement membrane precedes most glomerular diseases. However, little is known about the regulation...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Schell, Christoph, Rogg, Manuel, Suhm, Martina, Helmstädter, Martin, Sellung, Dominik, Yasuda-Yamahara, Mako, Kretz, Oliver, Küttner, Victoria, Suleiman, Hani, Kollipara, Laxmikanth, Zahedi, René P., Sickmann, Albert, Eimer, Stefan, Shaw, Andrey S., Kramer-Zucker, Albrecht, Hirano-Kobayashi, Mariko, Abe, Takaya, Aizawa, Shinichi, Grahammer, Florian, Hartleben, Björn, Dengjel, Jörn, Huber, Tobias B.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468651/
https://ncbi.nlm.nih.gov/pubmed/28536193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617004114
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