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Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase

Cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water and uses the released free energy to pump protons against the transmembrane proton gradient. To better understand the proton-pumping mechanism of the wild-type (WT) CcO, much attention has been given to the mutation of amino acid...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Liang, Ruibin, Swanson, Jessica M. J., Wikström, Mårten, Voth, Gregory A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468613/
https://ncbi.nlm.nih.gov/pubmed/28536198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703654114
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