Spinocerebellar Ataxia Type 2 Is Associated with the Extracellular Loss of Superoxide Dismutase but Not Catalase Activity

BACKGROUND: Spinocerebellar ataxia type 2 (SCA2) is an inherited and still incurable neurodegenerative disorder. Evidence suggests that pro-oxidant agents as well as factors involved in antioxidant cellular defenses are part of SCA2 physiopathology. AIM: To assess the influence of superoxide dismuta...

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Bibliographic Details
Published in:Front Neurol
Main Authors: Almaguer-Gotay, Dennis, Almaguer-Mederos, Luis E., Aguilera-Rodríguez, Raul, Rodríguez-Labrada, Roberto, Cuello-Almarales, Dany, Estupiñán-Domínguez, Annelié, Velázquez-Pérez, Luis C., González-Zaldívar, Yanetza, Vázquez-Mojena, Yaimé
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468381/
https://ncbi.nlm.nih.gov/pubmed/28659860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2017.00276
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