Phase Ib Study of Enzalutamide in Combination with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer

PURPOSE: Preclinical evidence suggests that both docetaxel and enzalutamide target androgen receptor translocation and signaling. This phase Ib study assessed the safety, tolerability, and pharmacokinetics of docetaxel when administered with enzalutamide as first-line systemic chemotherapy in men wi...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Morris, Michael J., Rathkopf, Dana E., Novotny, William, Gibbons, Jacqueline A., Peterson, Amy C., Khondker, Zakaria, Ouatas, Taoufik, Scher, Howard I., Fleming, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468167/
https://ncbi.nlm.nih.gov/pubmed/26858312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2638
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