Phase I pharmacokinetic and biodistribution study with escalating doses of (223)Ra-dichloride in men with castration-resistant metastatic prostate cancer

PURPOSE: (223)Ra-Dichloride ((223)Ra) is a novel bone-seeking alpha-emitter that prolongs survival in patients with castration-resistant metastatic prostate cancer. We conducted a study to better profile the pharmacokinetics, pharmacodynamics, and biodistribution of this agent. METHODS: Ten patients...

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Udgivet i:Eur J Nucl Med Mol Imaging
Main Authors: Carrasquillo, Jorge A., O’Donoghue, Joseph A., Pandit-Taskar, Neeta, Humm, John L., Rathkopf, Dana E., Slovin, Susan F., Williamson, Matthew J., Lacuna, Kristine, Aksnes, Anne-Kirsti, Larson, Steven M., Scher, Howard I., Morris, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468165/
https://ncbi.nlm.nih.gov/pubmed/23653243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-013-2427-6
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