Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells

Sorafenib is currently used to treat advanced and/or unresectable hepatocellular carcinoma (HCC), but the increase of the median survival was only 3 months. Moreover, sorafenib has severe side effects and patients develop resistance quickly. Epigenetic alterations such as DNA methylation play a deci...

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Bibliografiske detaljer
Udgivet i:Int J Oncol
Main Authors: Abeni, Edoardo, Salvi, Alessandro, Marchina, Eleonora, Traversa, Michele, Arici, Bruna, De Petro, Giuseppina
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467784/
https://ncbi.nlm.nih.gov/pubmed/28560380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2017.4019
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