Pan-cancer analysis reveals technical artifacts in TCGA germline variant calls

BACKGROUND: Cancer research to date has largely focused on somatically acquired genetic aberrations. In contrast, the degree to which germline, or inherited, variation contributes to tumorigenesis remains unclear, possibly due to a lack of accessible germline variant data. Here we called germline va...

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Publicat a:BMC Genomics
Autors principals: Buckley, Alexandra R., Standish, Kristopher A., Bhutani, Kunal, Ideker, Trey, Lasken, Roger S., Carter, Hannah, Harismendy, Olivier, Schork, Nicholas J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467262/
https://ncbi.nlm.nih.gov/pubmed/28606096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-3770-y
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