Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase

[Image: see text] Acetylcholinesterase (AChE) is an essential enzyme that can be targeted by organophosphorus (OP) compounds, including nerve agents. Following exposure to OPs, AChE becomes phosphylated (inhibited) and undergoes a subsequent aging process where the OP–AChE adduct is dealkylated. The...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Yoder, Ryan J., Zhuang, Qinggeng, Beck, Jeremy M., Franjesevic, Andrew, Blanton, Travis G., Sillart, Sydney, Secor, Tyler, Guerra, Leah, Brown, Jason D., Reid, Carolyn, McElroy, Craig A., Doğan Ekici, Özlem, Callam, Christopher S., Hadad, Christopher M.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467195/
https://ncbi.nlm.nih.gov/pubmed/28626522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00037
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