Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase

[Image: see text] Acetylcholinesterase (AChE) is an essential enzyme that can be targeted by organophosphorus (OP) compounds, including nerve agents. Following exposure to OPs, AChE becomes phosphylated (inhibited) and undergoes a subsequent aging process where the OP–AChE adduct is dealkylated. The...

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Publicado en:ACS Med Chem Lett
Autores principales: Yoder, Ryan J., Zhuang, Qinggeng, Beck, Jeremy M., Franjesevic, Andrew, Blanton, Travis G., Sillart, Sydney, Secor, Tyler, Guerra, Leah, Brown, Jason D., Reid, Carolyn, McElroy, Craig A., Doğan Ekici, Özlem, Callam, Christopher S., Hadad, Christopher M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467195/
https://ncbi.nlm.nih.gov/pubmed/28626522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00037
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