Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia

Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan which accumulates in patients with impaired renal function, such as chronic kidney disease (CKD). IS is a well-known nephrovascular toxin but little is known about its effects on central nervous...

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Foilsithe in:Front Pharmacol
Main Authors: Adesso, Simona, Magnus, Tim, Cuzzocrea, Salvatore, Campolo, Michela, Rissiek, Björn, Paciello, Orlando, Autore, Giuseppina, Pinto, Aldo, Marzocco, Stefania
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2017
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466960/
https://ncbi.nlm.nih.gov/pubmed/28659803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00370
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