Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member of sirtuin family, plays a dual role either in cancer promotion or suppression. There is no report about the role of SIRT1 in the human chondrosarcoma cells. Resveratrol is a potent activator of SIRT1. However, it...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Chao, Sung-Chuan, Chen, Ying-Ju, Huang, Kuo-How, Kuo, Kuan-Lin, Yang, Ting-Hua, Huang, Kuo-Yuan, Wang, Ching-Chia, Tang, Chih-Hsin, Yang, Rong-Sen, Liu, Shing-Hwa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466619/
https://ncbi.nlm.nih.gov/pubmed/28600541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03635-7
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