Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of α(V)β(3) Integrin Activity

Cyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α (V) β (3) integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imagin...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Hedhli, Jamila, Czerwinski, Andrzej, Schuelke, Matthew, Płoska, Agata, Sowinski, Paweł, Hood, Lukas La, Mamer, Spencer B., Cole, John A., Czaplewska, Paulina, Banach, Maciej, Dobrucki, Iwona T., Kalinowski, Leszek, Imoukhuede, Princess, Dobrucki, Lawrence W.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466598/
https://ncbi.nlm.nih.gov/pubmed/28600529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03224-8
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