Structural and functional dissection reveals distinct roles of Ca(2+)-binding sites in the giant adhesin SiiE of Salmonella enterica

The giant non-fimbrial adhesin SiiE of Salmonella enterica mediates the first contact to the apical site of epithelial cells and enables subsequent invasion. SiiE is a 595 kDa protein composed of 53 repetitive bacterial immunoglobulin (BIg) domains and the only known substrate of the SPI4-encoded ty...

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Publicado en:PLoS Pathog
Autores principales: Peters, Britta, Stein, Johanna, Klingl, Stefan, Sander, Nathalie, Sandmann, Achim, Taccardi, Nicola, Sticht, Heinrich, Gerlach, Roman G., Muller, Yves A., Hensel, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466336/
https://ncbi.nlm.nih.gov/pubmed/28558023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006418
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