Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions

Current methods for freezing mesenchymal stromal cells (MSCs) result in poor post-thaw function, which limits the clinical utility of these cells. This investigation develops a novel approach to preserve MSCs using combinations of sugars, sugar alcohols, and small-molecule additives. MSCs frozen usi...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Pollock, Kathryn, Samsonraj, Rebekah M., Dudakovic, Amel, Thaler, Roman, Stumbras, Aron, McKenna, David H., Dosa, Peter I., van Wijnen, Andre J., Hubel, Allison
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466057/
https://ncbi.nlm.nih.gov/pubmed/28178884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0347
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