Inhibition of Coxsackievirus B3 Replication by Small Interfering RNAs Requires Perfect Sequence Match in the Central Region of the Viral Positive Strand

Coxsackievirus B3 (CVB3) is the most common causal agent of viral myocarditis, but existing drug therapies are of limited value. Application of small interfering RNA (siRNA) in knockdown of gene expression is an emerging technology in antiviral gene therapy. To investigate whether RNA interference (...

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Hlavní autoři: Yuan, Ji, Cheung, Paul K. M., Zhang, Huifang M., Chau, David, Yang, Decheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC546545/
https://ncbi.nlm.nih.gov/pubmed/15681418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.4.2151-2159.2005
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