The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms. Here we show that the ATP-binding cassette transporter A1...

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Publicat a:Nat Commun
Autors principals: Castella, Barbara, Kopecka, Joanna, Sciancalepore, Patrizia, Mandili, Giorgia, Foglietta, Myriam, Mitro, Nico, Caruso, Donatella, Novelli, Francesco, Riganti, Chiara, Massaia, Massimo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465356/
https://ncbi.nlm.nih.gov/pubmed/28580927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15663
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