Identification of cellular targets involved in cardiac failure caused by PKI in oncology: an approach combining pharmacovigilance and pharmacodynamics

AIMS: The aims of the present study were to evaluate the risk of cardiac failure (CF) associated with 15 anticancer protein kinase inhibitors (PKIs) through a case/noncase analysis and to identify which PK(s) and pathways are involved in PKI‐induced CF. METHODS: In order to evaluate the risk of CF,...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Patras de Campaigno, Emilie, Bondon‐Guitton, Emmanuelle, Laurent, Guy, Montastruc, Francois, Montastruc, Jean‐Louis, Lapeyre‐Mestre, Maryse, Despas, Fabien
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Drug Safety
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465347/
https://ncbi.nlm.nih.gov/pubmed/28098949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13238
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