Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women

AIMS: Diabetes mellitus can inhibit cytochrome P450 3A4, an enzyme responsible for the metabolism of nifedipine, used for the treatment of hypertension in pregnant women. We aimed to assess the effect of type 2 diabetes mellitus (T2DM) on the pharmacokinetics, placental transfer and distribution of...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Filgueira, Gabriela Campos de Oliveira, Filgueira, Osmany Alberto Silva, Carvalho, Daniela Miarelli, Marques, Maria Paula, Moisés, Elaine Christine Dantas, Duarte, Geraldo, Lanchote, Vera Lucia, Cavalli, Ricardo Carvalho
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Drugs in Pregnancy and Lactation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465346/
https://ncbi.nlm.nih.gov/pubmed/28042936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13226
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