Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation

Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the inflammation, are the pharmacological targets of...

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Bibliografske podrobnosti
izdano v:Front Neurol
Main Authors: Calvello, Rosa, Lofrumento, Dario Domenico, Perrone, Maria Grazia, Cianciulli, Antonia, Salvatore, Rosaria, Vitale, Paola, De Nuccio, Francesco, Giannotti, Laura, Nicolardi, Giuseppe, Panaro, Maria Antonietta, Scilimati, Antonio
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465243/
https://ncbi.nlm.nih.gov/pubmed/28649222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2017.00251
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