A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

We have previously identified a small-cell lung cancer cell line (NCI-H209) that expresses an aberrant, underphosphorylated form of the retinoblastoma protein RB1. Molecular analysis of RB1 mRNA from this cell line revealed a single point mutation within exon 21 that resulted in a nonconservative am...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kaye, F J, Kratzke, R A, Gerster, J L, Horowitz, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54650/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2168563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.17.6922
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