Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Somatic mutations that lead to constitutive activation of NRAS and KRAS proto-oncogenes are among the most common in human cancer and frequently occur in acute myeloid leukemia (AML). An inducible NRAS(V12)-driven AML mouse model has established a critical role for continued NRAS(V12) expression in...

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Bibliographische Detailangaben
Veröffentlicht in:Oncogene
Hauptverfasser: Pomeroy, E J, Lee, L A, Lee, R D W, Schirm, D K, Temiz, N A, Ma, J, Gruber, T A, Diaz-Flores, E, Moriarity, B S, Downing, J R, Shannon, K M, Largaespada, D A, Eckfeldt, C E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464975/
https://ncbi.nlm.nih.gov/pubmed/27991934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.471
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