Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4(+) T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration an...

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Udgivet i:eLife
Main Authors: Saitakis, Michael, Dogniaux, Stéphanie, Goudot, Christel, Bufi, Nathalie, Asnacios, Sophie, Maurin, Mathieu, Randriamampita, Clotilde, Asnacios, Atef, Hivroz, Claire
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464771/
https://ncbi.nlm.nih.gov/pubmed/28594327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23190
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