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P01.35 Inhibition of MutT homolog 1 (MTH1) in glioblastoma multiforme results in impaired cell migration and tumor growth

Objective: MutT homolog1 (MTH1) is required for survival of cancer cells. These have irregular redox formations resulting in the production of reactive oxygen species which damage the deoxynucleoside triphosphate pool and subsequent the DNA. MTH1 plays a crucial role by inhibiting the incorporation...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Timmer, M., Kannampuzha, S.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463689/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.111
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