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An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype

BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide associ...

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Published in:Biol Psychiatry
Main Authors: Direk, Nese, Williams, Stephanie, Smith, Jennifer A., Ripke, Stephan, Air, Tracy, Amare, Azmeraw T., Amin, Najaf, Baune, Bernhard T., Bennett, David A., Blackwood, Douglas H.R., Boomsma, Dorret, Breen, Gerome, Buttenschøn, Henriette N., Byrne, Enda M., Børglum, Anders D., Castelao, Enrique, Cichon, Sven, Clarke, Toni-Kim, Cornelis, Marilyn C., Dannlowski, Udo, De Jager, Philip L., Demirkan, Ayse, Domenici, Enrico, van Duijn, Cornelia M., Dunn, Erin C., Eriksson, Johan G., Esko, Tonu, Faul, Jessica D., Ferrucci, Luigi, Fornage, Myriam, de Geus, Eco, Gill, Michael, Gordon, Scott D., Jörgen Grabe, Hans, van Grootheest, Gerard, Hamilton, Steven P., Hartman, Catharina A., Heath, Andrew C., Hek, Karin, Hofman, Albert, Homuth, Georg, Horn, Carsten, Hottenga, Jouke Jan, Kardia, Sharon L.R., Kloiber, Stefan, Koenen, Karestan, Kutalik, Zoltán, Ladwig, Karl-Heinz, Lahti, Jari, Levinson, Douglas F., Lewis, Cathryn M., Lewis, Glyn, Li, Qingqin S, Llewellyn, David J., Lucae, Susanne, Lunetta, Kathryn L., MacIntyre, Donald J., Madden, Pamela, Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Milaneschi, Yuri, Montgomery, Grant W., Mors, Ole, Mosley, Thomas H., Murabito, Joanne M., Müller-Myhsok, Bertram, Nöthen, Markus M., Nyholt, Dale R., O’Donovan, Michael C., Penninx, Brenda W., Pergadia, Michele L., Perlis, Roy, Potash, James B., Preisig, Martin, Purcell, Shaun M., Quiroz, Jorge A., Räikkönen, Katri, Rice, John P., Rietschel, Marcella, Rivera, Margarita, Schulze, Thomas G., Shi, Jianxin, Shyn, Stanley, Sinnamon, Grant C., Smit, Johannes H., Smoller, Jordan W., Snieder, Harold, Tanaka, Toshiko, Tansey, Katherine E., Teumer, Alexander, Uher, Rudolf, Umbricht, Daniel, Van der Auwera, Sandra, Ware, Erin B., Weir, David R., Weissman, Myrna M., Willemsen, Gonneke, Yang, Jingyun, Zhao, Wei, Tiemeier, Henning, Sullivan, Patrick F.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462867/
https://ncbi.nlm.nih.gov/pubmed/28049566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.11.013
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