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Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole
Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment. Using freeze fracture electron microscopy, we show here that the yeast NPC orthologs, Ncr1p and Npc2p, are essential f...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5462540/ https://ncbi.nlm.nih.gov/pubmed/28590904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25960 |
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