Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability

While up to 25% of ovarian cancer (OVCA) cases are thought to be due to inherited factors, the majority of genetic risk remains unexplained. To address this gap, we sought to identify previously undescribed OVCA risk variants through the whole exome sequencing (WES) and candidate gene analysis of 48...

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Publicat a:PLoS One
Autors principals: Stafford, Jaime L., Dyson, Gregory, Levin, Nancy K., Chaudhry, Sophia, Rosati, Rita, Kalpage, Hasini, Wernette, Courtney, Petrucelli, Nancie, Simon, Michael S., Tainsky, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462348/
https://ncbi.nlm.nih.gov/pubmed/28591191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178450
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