Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability

While up to 25% of ovarian cancer (OVCA) cases are thought to be due to inherited factors, the majority of genetic risk remains unexplained. To address this gap, we sought to identify previously undescribed OVCA risk variants through the whole exome sequencing (WES) and candidate gene analysis of 48...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Stafford, Jaime L., Dyson, Gregory, Levin, Nancy K., Chaudhry, Sophia, Rosati, Rita, Kalpage, Hasini, Wernette, Courtney, Petrucelli, Nancie, Simon, Michael S., Tainsky, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462348/
https://ncbi.nlm.nih.gov/pubmed/28591191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178450
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