Blockade of adenosine A2A receptor enhances CD8(+) T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

BACKGROUND: Cancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune clearance via inhibiting T cells response. To date, the role of A2AR in head and neck squamous cell carcinoma (HNSCC) has not been investiga...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Principais autores: Ma, Si-Rui, Deng, Wei-Wei, Liu, Jian-Feng, Mao, Liang, Yu, Guang-Tao, Bu, Lin-Lin, Kulkarni, Ashok B., Zhang, Wen-Feng, Sun, Zhi-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461710/
https://ncbi.nlm.nih.gov/pubmed/28592285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0665-0
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