Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides

Phosphorothioate-modified antisense oligodeoxynucleotides (ASOs) are used to suppress gene expression by inducing RNase H-mediated cleavage with subsequent degradation of the target mRNA. However, previous observations suggest that ASO/RNase H can also result in the generation of stable mRNA cleavag...

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Hauptverfasser: Hasselblatt, Peter, Hockenjos, Birgit, Thoma, Christian, Blum, Hubert E., Offensperger, Wolf-Bernhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC546143/
https://ncbi.nlm.nih.gov/pubmed/15640448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki155
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