Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides

Phosphorothioate-modified antisense oligodeoxynucleotides (ASOs) are used to suppress gene expression by inducing RNase H-mediated cleavage with subsequent degradation of the target mRNA. However, previous observations suggest that ASO/RNase H can also result in the generation of stable mRNA cleavag...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Hasselblatt, Peter, Hockenjos, Birgit, Thoma, Christian, Blum, Hubert E., Offensperger, Wolf-Bernhard
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2005
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC546143/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15640448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gki155
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