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Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs

Influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. To facilitate cost-effective growth, vaccine strains are serially passaged under production conditions, which frequently results in mutations of the major anti...

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Detalles Bibliográficos
Publicado en:mBio
Main Authors: Harding, Alfred T., Heaton, Brook E., Dumm, Rebekah E., Heaton, Nicholas S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461409/
https://ncbi.nlm.nih.gov/pubmed/28588131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00669-17
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