Long-Term Persistence of Cell-Mediated and Humoral Responses to A(H1N1)pdm09 Influenza Virus Vaccines and the Role of the AS03 Adjuvant System in Adults during Two Randomized Controlled Trials

We investigated the role of AS03(A) (here AS03), an α-tocopherol oil-in-water emulsion-based adjuvant system, on the long-term persistence of humoral and cell-mediated immune responses to A(H1N1)pdm09 influenza vaccines. In two studies, a total of 261 healthy adults (≤60 years old) were randomized t...

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Veröffentlicht in:Clin Vaccine Immunol
Hauptverfasser: van der Most, Robbert G., Clément, Frédéric, Willekens, Julie, Dewé, Walthère, Walravens, Karl, Vaughn, David W., Leroux-Roels, Geert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Clinical Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461372/
https://ncbi.nlm.nih.gov/pubmed/28446441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00553-16
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