TIGIT signalling pathway negatively regulates CD4(+) T‐cell responses in systemic lupus erythematosus

B‐lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T‐cell‐dependent, and CD4(+) T‐cell activation is essential to SLE pathogenesis. However, the mechanism of the deregulation of CD4(+) T cells in SLE is largely unknown. T‐cell immunoglobulin and ITIM domain (TIGIT) is a new inhibito...

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Bibliografiske detaljer
Udgivet i:Immunology
Main Authors: Mao, Lie, Hou, Hongyan, Wu, Shiji, Zhou, Yu, Wang, Juan, Yu, Jing, Wu, Xiaohui, Lu, Yanfang, Mao, Liyan, Bosco, Munyemana Jean, Wang, Feng, Sun, Ziyong
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461105/
https://ncbi.nlm.nih.gov/pubmed/28108989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12715
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