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TOG–tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation

XMAP215, CLASP, and Crescerin use arrayed tubulin-binding tumor overexpressed gene (TOG) domains to modulate microtubule dynamics. We hypothesized that TOGs have distinct architectures and tubulin-binding properties that underlie each family’s ability to promote microtubule polymerization or pause....

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Bibliografische gegevens
Gepubliceerd in:J Cell Biol
Hoofdauteurs: Byrnes, Amy E., Slep, Kevin C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461023/
https://ncbi.nlm.nih.gov/pubmed/28512144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610090
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