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TOG–tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation

XMAP215, CLASP, and Crescerin use arrayed tubulin-binding tumor overexpressed gene (TOG) domains to modulate microtubule dynamics. We hypothesized that TOGs have distinct architectures and tubulin-binding properties that underlie each family’s ability to promote microtubule polymerization or pause....

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Byrnes, Amy E., Slep, Kevin C.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461023/
https://ncbi.nlm.nih.gov/pubmed/28512144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610090
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